IMPLANTABLE MEMBRANES
Accelerate tissue regeneration!
Implantable membranes for surgical procedures
A collagen mesh represents an ideal scaffold that supports cell and tissue healing in reconstructive surgery. Viscofan BioEngineering’s unique bovine fibrous collagen type-I implantable membranes retain an in-vivo like structure with excellent proven biocompatibility and biodegradability. They provide natural signals for better cell attachment, growth, and differentiation, thereby enabling an accelerated tissue regeneration.
Our Collagen Medical Reel membrane (20 µm) is established in pre-clinical development and has been tested in joint development collaborations in a number of applications in regenerative medicine.
Our goal is to develop novel therapies in cardiology, urology, dermatology and dentistry based on our collagen I based membranes together with academic and clinical partners.
Xenograft for urether stricture repair
Transplantation of xenografts with human urothelial 3D-tissue grown on a cell carrying membrane into mini-pigs with urethra stricture.
Outcome: Reconstruction of the urothelial tissue and closure of the urothelial layer.
Conclusion: The collagen membrane increased the stability of the cell-seeded implants supporting survival and growth of urothelial cells leading to a complete regeneration of the porcine urethra.
Reference: Aufderklamm S et al., 2016
Underlayment in split skin grafts (SSG)
Transplantation of a SSG supported by a collagen cell carrying membrane into rats with tissue defects.
Outcome: The collagen cell carrier supported SSGs exhibited superior gross elasticity and viscoelasticity without causing inflammation, adverse reactions or scar tissue formation.
Conclusion: The collagen scaffold improves the quality of SSGs in wound management and reconstructive surgery.
Reference: Schwarz A et al., 2012
Barrier membrane for dental repair
Implantation of a Viscofan BioEngineering collagen scaffold as a barrier membrane for guided bone regeneration (GBR) in rats.
Outcome: Normal host-tissue reaction in comparison to porcine-sourced barrier membrane, no material fragmentation up to day 60.
Conclusion: Full biocompatibility, suitable for GBR indications.
Reference: Lindner C et al., 2022
Cell culture model for DPPSCs
Outcome: DPPSCs grew with high affinity, homogenously on the collagen scaffold. Osteogenic differentiation involved high level of calcification and expression of osteogenic and adhesion markers.
Conclusion: DPSSC-Collagen membrane cultures represent a model for osteogenic differentiation.
Reference: Nunez-Toldra R et al., 2017
Cornea and retina repair
Establishment of cell layers on collagen membranes using cornea endothelial / epithelial cells, iris pigment epithelial cells or retinal epithelial cells. Implantation studies in small animal models.
Features: Excellent biocompatibility, degradability kinetics adjustable by variation of membrane thickness.
What is your need in implantology?
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Pipeline
Viscofan BioEngineering is developing its own pipeline of products in regenerative medicine in collaboration with renowned partners and consortia with the goal to promote new breakthroughs in medical development. We are open to partnering!
Establish your own implantable membrane!
The Collagen Medical Reel membrane is a universal 20 µm thin scaffold for adherent primary cells and stem cells for in vitro and in vivo use. It creates a natural environment for cell attachment, growth and differentiation in applications ranging from simple cell monolayer cultures to the reconstruction of complex 3D tissue cultures on top of the membrane.
As a universal matrix, or collagen membrane in medical quality facilitates the development of cell-based assays with authentic cell performance. Strong and biocompatible it also serves perfectly as a cell-supporting, suturable carrier for pinpointed cell implantation.
The following primary cells have been tested on our 20 µm collagen membrane:
Heart & vascular system
Heart & vascular system
Eyes
Eyes
Bone & Cartilage
Bone & Cartilage
Nervous system
Nervous system
Liver & Pancreas
Liver & Pancreas
Skin
Skin
Urogenital tract
Urogenital tract
