We are interested in expanding our activities and welcome collaborations for joint research and development of novel medical technologies.
Native collagen I fibers provide a natural cellular scaffold
Due to its central role in cell adhesion and organ formation, collagen represents an ideal cell scaffold that supports natural growth and differentiation. Using an advanced technology for collagen purification and processing, our unique fibrous collagen retains the in-vivo-like structure of insoluble collagen fibers with excellent proven biocompatibility and biodegradability. Our products provide natural signals for better attachment, growth, differentiation, thereby enabling an authentic cell perfomance and an accelerated tissue formation. Viscolma® collagen suspension is an ideal material for coating of medical devices, available in research and medical grade quality.
The following descriptions summarize some medical technology applications of Viscofan BioEngineering's collagen products:
Urethra stricture repair
Around 300.000 patients suffer from urethra stricture every year and require a urethra substitute to recover normal urinary function. In a collaboration with the Department of Urology at the University of Tübingen, Viscofan BioEngineering is working on a tissue engineering project for urethral reconstructive surgery.
In first pre-clinical in-vivo experiments, an urothelial 3D-tissue has been established on the Collagen Cell Carrier (CCC) by using human urothelial cells. The xenograft has been successfully transplanted into minipigs, resulting in the reconstruction of the urothelial tissue and the closure of the urothelial layer. The investigators conclude that „the CCC seems to increase the stability of the cell-seeded implants and may support survival and growth of urothelial cells leading to a complete regeneration of the porcine urethra“ [Aufderklamm S et al., 2016].
Collagen membranes for skin regeneration
In reconstructive surgery, the quality of split-thickness skin grafts is often poor. Viscofan BioEngineering's CCC has been evaluated in rats as an underlayment in split skin graft (SSG) transplantation for covering tissue defects [Rahmanian-Schwarz A et al., 2012]. The CCC-supported SSGs exhibited superior gross elasticity and viscoelasticity without causing inflammation, adverse reactions or scar tissue formation. The CCC collagen scaffold therefore represents an opportunity to improve the quality of SSGs in the complex wound management and reconstructive surgery.
Collagen membranes for dental repair
In collaboration with an industry partner, Viscofan BioEngineering has developed a process for the production of bovine collagen membranes that can be used as a barrier membrane in dental applications.
In addition, osteogenic differentiation of dental pulp pluripotent-like stem cells (DPPSC) cultured on Viscofan BioEngineering‘s collagen I cell carrier CCC has been demonstrated [Nunez-Toldra R et al., 2017]. The analysis of the scaffold surface and cell morphology by electron microscopy revealed the high affinity of DPPSC to grow on CCC, the homogenous cell distribution and the high level of calcification at the final stage of the differentiation. The differentiation of the DPPSC into osteogenic lineage has been confirmed by the expression of osteogenic and adhesion markers.